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Routine II opioid analgesics expose end users towards the risks of addiction, abuse, and misuse; You will find a bigger hazard for overdose and Loss of life with prolonged-release opioids due to much larger degree of active opioid current (see Black Box Warnings)Concomitant usage of oxycodone with CYP3A4 inducers or discontinuation of the CYP3A4 in